LCMS-8060 | Triple Quadrupole LC-MS

The Shimadzu LCMS-8060 features an optimized ion guide and new technologies incorporated in the ion transport optical system. As a result, the ion sampling efficiency and ion focusing capability are significantly increased, to achieve improved sensitivity, approx. 3 times better than that of the LCMS-8050. Inheriting the high-speed performance of the LCMS-8050, this flagship model in the UFMS series features both the world’s highest level of sensitivity and the world’s highest throughput. It is capable of detecting ultra trace components in complex matrices, which have been difficult to detect to date, both quickly and with high sensitivity. This will contribute to further improvements in data quality in all types of trace quantitative analysis applications, such as for biological samples, which requires the highest level of sensitivity.

LCMS-8060 features

• Sensitivity: By redefining the ion focusing capability on the UF-Qarray, the LCMS-8060 brings a meaningful impact to quantitative detection and opens new opportunities for scientists to deliver solutions that make a true difference.
• Speed: Inspired by the need to balance advanced high speed MS/MS detection technologies with unrivalled LC performance, we were the first mass spectrometry company in the world to deliver a scan speed of 15,000 u/sec and a polarity switching speed of 15 msec. In the LCMS-8060 the scan speed is now increased to 30,000 u/sec and a polarity switching speed of 5 msec making a real difference to working better and faster.
• Solutions: High-sensitivity quantitation of intact catecholamines (CAs) in human plasma.
• Stability: The robustness of the LCMS-8060 and modified ion optics was also assessed by injecting 2400 samples of femto-gram levels of alprazolam spiked into protein-precipitated human plasma extracts over a 6 day period (over 400 samples were injected each day). The RSD of peak area response was 5% over this test period, using a deuterated internal standard (alprazolam-d5) the RSD was 3.5%. As part of the robustness test the vacuum system was vented to model a transient power failure with no effect on signal response or baseline noise level.