Extended live cell imaging requires strict control of temperature, humidity, CO2 and O2 levels in order to maintain sample integrity and focus position. The cellVivo incubation system’s innovative workflow-optimized design provides precise and user-friendly control of even the most sensitive samples. The unique design allows one-handed manipulation of both the incubator and specimen, thus minimizing exposure to the external environment. Intelligent software enables easy set-up and ensures continuous monitoring of conditions, even remotely. cellVivo is a modular and flexible ‘one-size-fits-all’ incubation system, which is fully adaptable to IX73 and IX83 inverted microscopes. Further flexibility is provided by the various enclosure types and components, which can even allow for advanced laser-safe functionality.