Imaging mass spectrometry is a revolutionary new technology and the accurate and high resolution mass images from the Shimadzu iMScope will drive your research to the next level
The iMScope TRIO instrument is a combination of an optical microscope which allows the observation of high resolution morphological images, with a mass spectrometer which identifies and visualises the distribution of specific molecules. Superimposing the two images obtained based on these very different principles,has created a significant new research tool, the imaging mass microscope.
Featues of the iMScope TRIO
- High spatial resolution: high-resolution imaging offered by optical microscopes is required not only for pharmacokinetic analysis, but also for toxicity testing and toxicity mechanism analysis. Analysis of the retina and skin requires imaging with high spatial resolution.
- Overlaying MS images and optical microscope morphological images reveals the difference between the amounts of specific molecules in each minute organ and can relate molecular distribution to the biological functions of an organelle and morphological changes.
- High speed analysis: samples are measured at a fast 6 pixels per second*, dramatically shortening your experiment time.
- In pharmacokinetic analysis, the iMScope TRIO enables the distribution of unchanged and metabolized drugs to be simultaneously mapped in a single measurement, without any labeling. The laser diameter used during mass spectrometry imaging with the iMScope TRIO is continuously variable from 5 to 200 μm, offering low to high spatial resolution. This helps ensure that analyses are performed as efficiently as possible.
- MS and MS/MS Imaging: Even if a molecule cannot be identified in the MS spectra, due to multiple molecules coexisting at the same mass (peak), these can be distinguished and visualized (rendered to images) by MS/MS analysis.