Online extraction system for MS and LC-MS or Sample Collector coupling. The fully automated DBS-MS 500 from CAMAG contains state-of-the-art technology to analyze target substances out of a DBS (Dried Blood Spot) on a DBS card. The DBS is directly eluted in the extraction chamber and the analytes are guided online to the analytical system of choice. Sample processing is automated, including the application of an internal standard through a high precision sprayer and a barcode assignment from the DBS card. In addition to the analytical results, a picture of each DBS card before and after extraction and the run parameters are reported to maintain full traceability and the highest quality.