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Nexera UC | Supercritical Fluid Extraction


Nexera UC | Supercritical Fluid Extraction

Advances in column technology have led to a renewed interest in supercritical fluid chromatography (SFC), the Shimadzu Nexera UC, which uses a supercritical fluid as mobile phase. Compared to liquid, supercritical fluids have low viscosity and high diffusivity. By combining SFC with Supercritical fluid extraction (SFE), which utilizes the high permeability and diffusivity of supercritical fluids, the extraction and analysis of target components from solid samples can be automated. The new analytical technology “Unified Chromatography” improves the analytical workflow by integrating sample extraction, analysis by various separation modes, and high-sensitivity detection.


Nexera UC features

  • Higher resolution: The analysis time can be effectively shortened because an excellent chromatographic resolution can be maintained even at higher flow rates than those typically used for HPLC.
  • Available for both UHPLC and SFC analysis using a single system, Nexera UC/s: Separation results can be quickly obtained during method development by screening with both SFC and UHPLC.
  • Small volume fractionation: By using a fraction collector, small-volume fractionation is also possible (ex:1.5 mL vials).
  • Fully automated on-line extraction and separation: Target compounds are extracted from solid samples, and then automatically transferred to SFC.
  • Nexera UC reduces environmental impact: By using SFC, the consumption of organic solvent is reduced by 94.2%, compared to the normal-phase.
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