Glass Reactors and Process Equipment
Buchiglas glass reactors and process equipment guarantee the best process performance in labs, pilot plants/kilo labs and production. From laboratory synthesis through scale-up to production. Buchi apparatus and systems are built with Swiss made highest quality borosilicate glass components and various other components made of highly corrosion-resistant materials such as glass-lined steel, fluoropolymers and Hastelloy®. – Buchi is your competent partner.
FEATURED PRODUCTS
Multipurpose glass reactor for small volumes Glass reactor: 5, 10, 15 liter Pressure: -1.0 (FV) to +1.0 bar Temperature: -60 °C (optional -90 °C) ...
More About miniPilot® - miniplant pilot reactor
miniPilot® - miniplant pilot reactor 
Multipurpose glass reactor for small volumes
Glass reactor: 5, 10, 15 liter
Pressure: -1.0 (FV) to +1.0 bar
Temperature: -60 °C (optional -90 °C) to +200 °C
Material: Borosilicate glass 3.3, PTFE, PFA, PEEK
A clean-room setup and other materials are available to meet your specific process requirements.
With the Buchiglas miniPilot® product family (reactor, nutsche filter, scrubber) they offer miniplant pilot reactors for chemical process development, scale-up, process simulation and kilo-scale production.
The reactors’ explosion-proof design (ATEX) and inert materials allow safe processing of solvents and acids in a completely sealed reaction vessel. The compact standard reactor setup can easily be modified, interchangeable reaction vessels of 5, 10 and 15 liter including interchangeable stirrers are available.
The reaction vessel is installed on a lifting / lowering device to simplify opening and cleaning. The distillation glass overhead is built with flexible ball-socket joints for multiple chemical reactions under full vacuum.
Buchglas produces complete solutions for chemical processing: Reactor systems including accessories like sampling devices, pH probes, rectification columns with structured packing, process monitoring and control as well as integration of auxiliary equipment such as temperature control units, nutsche filters / dryers, gas scrubbers or mixing vessels.
Package / Options
Standard package
- Interchangeable 5, 10 and 15 liter jacketed glass reactor
- Baffle with Pt100 temperature sensor
- Continuous adjustable agitator speed, 0-600 rpm
- Dry running mechanical seal
- Compact stainless steel frame, table or floor model, mobile
- ATEX Classification: 2G IIB
- CE, cGMP, TA-Luft
- CIP capable
- FDA conform, highly corrosion resistant materials: Glass, PTFE, PFA, PEEK
- Delivery fully assembled
- Complete documentation
Standard options
- Reactor lift for easy reactor opening, cleaning, stirrer exchange
- 3-wall reactor vessel for -90 °C chemistry
- Glass distillation overhead
- Sampling system
- Probes for pH, others
- CiP spray nozzle
- IQ, OQ, PQ
Typical applications for the miniPilot® – miniplant pilot reactor
- Chemical synthesis
- Extraction/evaporation
- Purification/crystallization
- Separation
- cGMP API production
- Peptide synthesis
- Process development
- Scale-up
- Cryogenic reactions
- Pilot plant/kilo lab
Multipurpose glass reactor for small volumes Glass reactor: 20 to 30 liter Pressure: -1.0 (FV) to +0.5 bar Temperature: -60 °C (optional -90 °C) to ...
More About midiPilot® - glass reactor for small volumes
midiPilot® - glass reactor for small volumes
Multipurpose glass reactor for small volumes
Glass reactor: 20 to 30 liter
Pressure: -1.0 (FV) to +0.5 bar
Temperature: -60 °C (optional -90 °C) to +200 °C
Material: Borosilicate glass 3.3, PTFE, PFA, PEEK
A clean-room setup and other materials are available to meet your specific process requirements.
The Buchiglas midiPilot is our sturdy multipurpose glass reactor for small volumes. It is specifically designed for applications in kilo lab, for chemical process development and cGMP-compliant API syntheses.
The reactors’ explosion-proof design (ATEX) and inert materials allow safe processing of solvents and acids in a completely sealed reaction vessel.
The compact reactor system can easily be modified: interchangeable reaction vessels of 20 and 30 liter including interchangeable stirrers are available. The glass reactor is equipped with a lifting / lowering device for easy and efficient opening and cleaning.
We produce complete solutions for chemical processing: Reactor systems including accessories like sampling devices, pH probes, rectification columns with structured packing, process monitoring and control as well as integration of auxiliary equipment such as temperature control units, nutsche filters / dryers, gas scrubbers or mixing vessels.
Package / Options
Standard package
- 20, 30 liter jacketed glass reactor, interchangeable
- Baffle with Pt100 temperature sensor
- Continuous adjustable agitator speed, 0-600 rpm
- Dry running mechanical seal
- Compact stainless steel frame, table or floor model, mobile
- ATEX Zone 1 (0), CE, cGMP
- CIP capable
- FDA conform, highly corrosion resistant
- Complete documentation
Standard options
- Reactor lift for easy reactor opening, cleaning, stirrer exchange
- 3-wall reactor vessel for -90 °C chemistry
- Glass distillation overhead
- Sampling system
- Probes for pH, others
- CiP spray nozzle
- IQ, OQ, PQ
Typical applications
- Chemical synthesis
- Extraction / evaporation
- Purification / crystallization
- Separation
- API synthesis
- Peptide synthesis
- Process development
- Scale-up
- Cryogenic reactions
- Small scale production
- Pilot plant / kilo lab
High-performance reactor systems for API synthesis, small scale production and pilot plant applications chemReactor CR – high-performance reacto...
More About chemReactor CR - high-performance reactor system
chemReactor CR - high-performance reactor system
High-performance reactor systems for API synthesis, small scale production and pilot plant applications
chemReactor CR – high-performance reactor system
Glass, glass-lined steel reactor: 15, 30, 60, 100, 160, 250 liter
Pressure: -1.0 (FV) to +0.5 bar
Temperature: -60 °C (-90 °C) to +200 °C
Material: Borosilicate glass 3.3, glass-lined steel, PTFE, PFA, tantalum
A clean-room setup and other materials are available to meet your specific process requirements.
Performance and reliability are key issues in the explosion proof design of Buchiglass reaction systems. The inert materials allow safe processing in a inert atmosphere of a wide range of solvents and acids in a completely sealed glass reaction system under full vacuum. Multiple chemical reaction steps are performed safely in the same setup.
The chemReactor system consists of:
Reactor with solid jacketed glass-lined steel bottom stands for solid construction, excellent heat transfer, stable process conditions and temperatures and a glass section to easily improve and control chemical reactions by visual observation.
Distillation glass overhead built with buchiflex components (unique flexible ball – socket joints) for multiple, reliable processes under full vacuum.
The CR type chemReactor is a multipurpose pilot reactor system for chemical process development, scale-up, process simulation and kilo-scale cGMP production in batch and semi-batch operation.
We produce complete solutions for chemical processing: Reactor systems including accessories like sampling devices, pH probes, rectification columns with structured packing, process monitoring and control. as well as integration of auxiliary equipment such as temperature control units, nutsche filters / dryers, scrubbers or mixing vessels.
Package / Options
Standard package
- Jacketed full glass / glass-lined steel reactor
- Multipurpose glass distillation overhead
- Stainless steel frame, supporting flexible glass superstructure
- ATEX Zone 1 (0), CE, cGMP
- CIP capable
- FDA conform, highly corrosion resistant
- Complete documentation
Standard options
- Reactor lift for easy opening (vessel cleaning)
- Sampling device
- pH monitoring and control
- Gas introduction (Nitrogen purging and active gas)
- Vacuum/exhaust piping
- Additional feeders/receivers
- Solid feeding
- Cryogenic vessel for low-temperature chemistry (-90 °C)
- In special glass lining or Hastelloy® C22
- Mixed systems with pressure reactor and vacuum distillation
- IQ, OQ, PQ
Typical applications
- Chemical synthesis
- Extraction/evaporation
- Purification/crystallization
- Separation
- API manufacturing
- Peptide production
- Process development
- Scale-up
- Cryogenic reactions
- Small scale production
- Pilot plant/kilo lab
Process equipment for pharmaceutical and chemical production Glass-lined steel reactor: 250 – 10’000 liter Pressure: -1.0 (FV) to +0.5 bar...
More About Production scale reactor systems
Production scale reactor systems
Process equipment for pharmaceutical and chemical production
Glass-lined steel reactor: 250 – 10’000 liter
Pressure: -1.0 (FV) to +0.5 bar
Temperature: -60 °C (-90 °C) to +200 °C
Material: Borosilicate glass 3.3, glass-lined steel, PTFE, PFA, tantalum
Chemical process equipment consisting of glass-lined reactors or mixing tanks with distillation overhead in borosilicate glass can be operated at full vacuum and low pressure. A large variety of chemicals can be processed in such plants due to the highly corrosion-resistant materials used. The design varies between multipurpose product / process-specific set ups.
Feeders and receivers are made of glass for smaller units and of glass-lined steel for larger setups. Shell and tube type heat exchangers are built with inner tubes made of borosilicate glass, glass-lined steel, silicon carbide, tantalum or other metals depending on process parameters and other requirements. Such reactor configurations are used for chemical synthesis, distillation, reflux distillation, solvent recovery, rectification and other processes.
Distillation glass overheads for large glass-lined chemical reactors are always customized according to the process and available space. Our 3-D engineering enables the integration/combination of large glass-lined reactors of different suppliers with our distillation glass overheads into a complete reaction system.
Buchiglass overheads are based on our unique, flexible and safe buchiflex glass joint system of DN15 – DN 600 components. These connections are used for glass piping to connect distillation columns, heat exchangers, feeders, receivers and valves.
Benefit from our long-term experience in the manufacturing of safe and reliable glass process equipment.
Typical application
- Vacuum distillation
- Reflux distillation
- Azeotropic distillation (phase separation)
- Evaporation to any desired consistency
- Multi-component reactions
- Gas introduction into liquid phase
- Rectification / stripping
- Extraction of multiphase mixture
- Crystallization
- Refluxing
- Multiple chemical reactions liquid/liquid, liquid/solid
- Low temperature chemistry