Glass Reactors and Process Equipment

miniPilot ® - miniplant pilot reactor

midiPilot – multipurpose glass reactor for small volumes 

• Glass reactor: 5, 10, 15 litre
• Pressure: -1.0 (FV) to +1.0 bar
• Temperature: -60 °C (optional -90 °C) to +200 °C
• Material: Borosilicate glass 3.3, PTFE, PFA, PEEK

A clean-room setup and other materials are available to meet your specific process requirements.

With the Buchiglas miniPilot® product family (reactor, nutsche filter, scrubber) they offer miniplant pilot reactors for chemical process development, scale-up, process simulation and kilo-scale production.

The reactors’ explosion-proof design (ATEX) and inert materials allow safe processing of solvents and acids in a completely sealed reaction vessel. The compact standard reactor setup can easily be modified, interchangeable reaction vessels of 5, 10 and 15 liter including interchangeable stirrers are available.

The reaction vessel is installed on a lifting / lowering device to simplify opening and cleaning. The distillation glass overhead is built with flexible ball-socket joints for multiple chemical reactions under full vacuum.

Buchglas produces complete solutions for chemical processing: Reactor systems including accessories like sampling devices, pH probes, rectification columns with structured packing, process monitoring and control as well as integration of auxiliary equipment such as temperature control units, nutsche filters/dryers, gas scrubbers or mixing vessels.

Standard miniPilot package

• Interchangeable 5, 10 and 15 litre jacketed glass reactor
• Baffle with Pt100 temperature sensor
• Continuous adjustable agitator speed, 0-600 rpm
• Dry running mechanical seal
• Compact stainless steel frame, table or floor model, mobile
• ATEX Classification: 2G IIB
• CE, cGMP, TA-Luft
• CIP capable
• FDA conform, highly corrosion-resistant materials: Glass, PTFE, PFA, PEEK
• Delivery fully assembled
• Complete documentation

Standard miniplant pilot reactor options

• Reactor lift for easy reactor opening, cleaning, stirrer exchange
• 3-wall reactor vessel for -90 °C chemistry
• Glass distillation overhead
• Sampling system
• Probes for pH, others
• CiP spray nozzle
• IQ, OQ, PQ

Glass reactor for small volumes applications

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midiPilot® - Laboratory glass reactor for small volumes

Multipurpose glass reactor for small volumes

• Glass reactor: 20 to 30 litre
• Pressure: -1.0 (FV) to +0.5 bar
• Temperature: -60 °C (optional -90 °C) to +200 °C
• Material: Borosilicate glass 3.3, PTFE, PFA, PEEK

A clean-room setup and other materials are available to meet your specific process requirements.

The Buchiglas midiPilot is our sturdy multipurpose glass reactor for small volumes. It is specifically designed for applications in kilo lab, for chemical process development and cGMP-compliant API syntheses.

The reactors’ explosion-proof design (ATEX) and inert materials allow safe processing of solvents and acids in a completely sealed reaction vessel.

The compact reactor system can easily be modified: interchangeable reaction vessels of 20 and 30-litre including interchangeable stirrers are available. The glass reactor is equipped with a lifting / lowering device for easy and efficient opening and cleaning.

We produce complete solutions for chemical processing: Reactor systems including accessories like sampling devices, pH probes, rectification columns with structured packing, process monitoring and control as well as integration of auxiliary equipment such as temperature control units, nutsche filters/dryers, gas scrubbers or mixing vessels.

Standard midiPilot package

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chemReactor CR - high-performance reactor system

chemReactor CR – high-performance reactor systems for API synthesis, small-scale production and pilot plant applications

• Glass, glass-lined steel reactor: 15, 30, 60, 100, 160, 250 liter
• Pressure: -1.0 (FV) to +0.5 bar
• Temperature: -60 °C (-90 °C) to +200 °C
• Material: Borosilicate glass 3.3, glass-lined steel, PTFE, PFA, tantalum

A clean-room setup and other materials are available to meet your specific process requirements.

Performance and reliability are key issues in the explosion-proof design of Buchiglass reaction systems. The inert materials allow safe processing in a inert atmosphere of a wide range of solvents and acids in a completely sealed glass reaction system under full vacuum. Multiple chemical reaction steps are performed safely in the same setup.

The chemReactor system consists of:

• Reactor with solid jacketed glass-lined steel bottom stands for solid construction, excellent heat transfer, stable process conditions and temperatures and a glass section to easily improve and control chemical reactions by visual observation.
• Distillation glass overhead built with buchiflex components (unique flexible ball-socket joints) for multiple, reliable processes under full vacuum.
• The CR type chemReactor is a multipurpose pilot reactor system for chemical process development, scale-up, process simulation and kilo-scale cGMP production in batch and semi-batch operation.
• We produce complete solutions for chemical processing: Reactor systems including accessories like sampling devices, pH probes, rectification columns with structured packing, process monitoring and control. as well as integration of auxiliary equipment such as temperature control units, nutsche filters/dryers, scrubbers or mixing vessels.

Standard CR package

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Production scale reactor systems

Process equipment for pharmaceutical and chemical production

• Glass-lined steel reactor: 250 – 10’000 litre
• Pressure: -1.0 (FV) to +0.5 bar
• Temperature: -60 °C (-90 °C) to +200 °C
• Material: Borosilicate glass 3.3, glass-lined steel, PTFE, PFA, tantalum

Chemical process equipment consisting of glass-lined reactors or mixing tanks with distillation overhead in borosilicate glass can be operated at full vacuum and low pressure. A large variety of chemicals can be processed in such plants due to the highly corrosion-resistant materials used. The design varies between multipurpose product / process-specific setups.

Feeders and receivers are made of glass for smaller units and of glass-lined steel for larger setups. Shell and tube type heat exchangers are built with inner tubes made of borosilicate glass, glass-lined steel, silicon carbide, tantalum or other metals depending on process parameters and other requirements. Such reactor configurations are used for chemical synthesis, distillation, reflux distillation, solvent recovery, rectification and other processes.

Distillation glass overheads for large glass-lined chemical reactors are always customized according to the process and available space. Our 3-D engineering enables the integration/combination of large glass-lined reactors of different suppliers with our distillation glass overheads into a complete reaction system.

Buchiglass overheads are based on our unique, flexible and safe buchiflex glass joint system of DN15 – DN 600 components. These connections are used for glass piping to connect distillation columns, heat exchangers, feeders, receivers and valves.

Benefit from our long-term experience in the manufacturing of safe and reliable glass process equipment.

Distillation glass overhead

• Unique flexible ball-socket joints
• Buchiflex DN15 – DN600 components
• Feed vessel for addition of liquids in glass / glass-lined steel
• Glass distillation column
• Rectification columns with reflux divider
• Packed glass columns
• Column packing such as raschig rings, ceramic saddle packing, structured packing with different separation efficiency in different materials
• Shell & tube type heat exchanger (glass / SiC) / Spiral (reflux) condenser batteries
• Receiver vessel for collection of distillate/condensate in glass / glass-lined steel
• Dean-Stark phase separator for azeotrope distillation
• Vacuum/pressure equalization and distribution (for semi-batch operation)
• Self-draining «buchiflex» glass piping

Production scale reactor systems applications

Download the Buchiglas Product Overview Brochure

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Nutsche filters 10 - 300 litre

Nutsche filters for reactors and pilot plants

• Glass vessel: 10, 30, 50, 100, 140, 300 litre
• Pressure: -1.0 (FV) to +0.5/ 1.0 bar
• Temperature: -60 °C to +150 °C (200 °C)
• Filter cloth: Mesh size 8 to 115 micron
• Material: Borosilicate glass 3.3, PTFE, PFA, ETFE

A clean-room setup and other materials are available to meet your specific process requirements.

Buchiglas nutsche filters can easily be combined with our reactors for solid/liquid separation after the synthesis. The inert materials allow safe processing in an inert atmosphere of a wide range of solvents and acids in a completely sealed (buchiflex) glass system under full vacuum.

The slurry is transferred into the filter. The solid content in the slurry is held back by the filter cloth forming a filter cake, while the filtrate runs away to the outlet valve in the bottom plate. The filtering stage ends when the filtrate is of small quantity, which can be shortened by squeezing the filter cake by turning the height adjustable stirrer.

The cake is removed easily from the top by opening the cover and lowering the glass filter vessel, which is attached to the lifting device. The same lifting device is used to lower the bottom for accessing the filter cloth for cleaning and exchange.

Standard package for the Nutsche filters for reactors and pilot plants

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Filter Reactors FR 10, FR 30 & FR 50

Filter Reactors for Pilot Plants and Kilo Labs

• Glass Vessel Capacities: 10, 30, 50 litres
• Pressure Range: FR 10: -1.0 (FV) to +1.0 bar, FR 30, FR 50: -1.0 (FV) to +0.5 bar
• Temperature Range: -60°C to +200°C
• Filter cloth: Mesh size 8 to 115 micron
• Material: Borosilicate glass 3.3, PTFE, PFA, ETFE

Buchiglas filter reactors are specifically designed for pilot plants and kilo laboratories. These systems combine a reactor and a filtration vessel in a single unit, enabling a wide range of processes and applications, including cGMP API synthesis, peptide synthesis, and cannabis extraction.

The filter reactors are available in three sizes, with 10 litre, 30 litre, and 50 litre reaction volumes. They feature a modular design that allows for easy configuration to meet your specific process requirements. Our filter reactor systems are distinguished by Swiss quality, safety, and reliability. They are modular, compact, and mobile, allowing for flexible handling and versatile applications. The straightforward operation and the ability to perform various processes in a single device make them particularly user-friendly.

These systems are turnkey, highly corrosion-resistant, and inert, making them ideal for demanding applications in laboratories and production. Certified to ATEX, CE, and cGMP standards, they offer the highest levels of safety and quality.

Standard Package

• Glass vessel with heating/cooling jacket
• Robust cover and bottom plate made from stainless steel with PFA coating
• Dry-running mechanical seal with ATEX stirrer drive
• Multi-stage stirrer, PFA coated
• Baffle, PFA coated with integrated temperature sensor Pt100
• Manual lowering device, 2-step, for vessel and bottom plate
• Swing-out mechanism for easy removal of filter cake
• Heating hoses and pull-safe connection ports to connect TCU
• Flexible, durable, and vacuum-tight buchiflex glass piping

Standard Options

• 4 standard configurations for glass upper section (GUS) available, customized solutions possible
• Measure/control of temperature, pressure/vacuum, stirrer speed, pH
• Sampling device
• CIP spray nozzle
• Clean room design (HPAPIs)
• Glass coating: Glassprotect-P, antistatic, shatter protection
• Additional material options for bottom plate/cover plate/stirrer: stainless steel 1.4404, Hastelloy® C22
• Heatable bottom plate made from stainless steel 1.4404, Hastelloy® C22
• Connection set: Reflux-Basic, Reflux Multipurpose
• Automation tailored to individual process needs
• Agitated height adjustable stirrer (hydraulic), stainless steel 1.4404, Hastelloy® C22

Typical Applications

• Chemical syntheses
• Evaporation / precipitation / crystallization
• Filtration / washing / drying
• Solid phase peptide synthesis (SPPS)
• cGMP API production
• Cannabis solvent extraction
• Scale-up

Explore the versatility and efficiency of our Filter Reactors – FR 10, FR 30, FR 50 for your specific needs. Contact us today for more information and to discuss your requirements!

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