LCMS

LCMS-9030 | Quadrupole Time-of-Flight LC-MS

The Shimadzu LCMS-9030 quadrupole time-of-flight (Q-TOF) mass spectrometer is a powerful instrument that integrates the world’s fastest and most sensitive quadrupole technology with TOF capabilities for accurate mass measurement.

The LCMS-9030 provides superior sensitivity for quantitative and qualitative analysis of samples over a wide concentration rane, including ultra-trace compounds. Patented technologies ensure high resolution and excellent mass measurement accuracy (MMA), supporting structure elucidation and identification of unknown compounds. High throughput is achieved with Shimadzu’s unique acceleration technologies designed for high-speed data acquisition.

LCMS-9030 features

High-Efficiency Quadrupole Technologies

• UFaccumulation™ (Pat. US 10020181): Ion accumulation in the collision cell, synchronized perfectly with short cycles of data acquisition, maximizes sensitivity.
• UFgrating™ (Pat. US 9048082): Shimadzu’s world-class manufacturing capability has enabled the ion acceleration electrode to be made with substantial mechanical strength. This grating is able to withstand the high voltages needed for ultrafast ion pulsing.
• UF-FlightTube™ (Patent Pending): Mass accuracy needs mass stability. Shimadzu’s temperature-controlled UF-FlightTube requires less frequent calibration, enabling you to run more samples.
• iRefTOF™ (Pat. US 8772708, 9490114): A computationally ideal electrostatic field has become a reality. Meticulously manufactured plate electrodes are stacked to create a reflectron which turns ions with no compromise in resolution or sensitivity.

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LCMS-8045 | Triple Quadrupole LC-MS

Equipped with a heated ESI probe, the Shimadzu LCMS-8045 has the highest sensitivity in its class. The heated ESI probe, high-temperature heating block, desolvation line (DL) and drying gas, all act to promote desolvation and prevent contamination due to the penetration of liquid droplets into the MS unit. This improves the robustness, so reliable and high-accuracy data can be obtained over the long term. The LCMS-8045 also achieves the world’s fastest scan speed (30,000 u/sec) and polarity switching speed (5 msec). These enable ultra-high-speed, high-sensitivity analysis. The excellent cost performance of this system is demonstrated in food safety, environmental analysis, and other quantitative analyses, it can be upgraded to the LCMS-8060.

LCMS-8045 features

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LCMS-2020 | Ultra Fast Liquid Chromatograph

The Shimadzu LCMS-2020 is optimized for the Prominence UFLC/UFLCXR Ultra Fast Liquid Chromatograph. Novel patent-pending technologies offer significantly enhanced scan speed and positive-negative ion polarity switching time, which are essential for UFLC, and simultaneously boost sensitivity. The instrument combines the excellent compound selectivity that is a feature of the mass spectrometer with significantly enhanced total productivity – from method development to analysis. The LCMS-2020 plays a useful role in a range of fields, including the synthesis of compounds in the pharmaceutical and chemical industries.

LCMS-2020 features

• UF Switching: To detect both positive and negative ions, analysis is performed while switching between the positive and negative ionization modes. The LCMS-2020 adopts patented high-voltage power supply technology (Patent: US7855355) to achieve an ultra-fast polarity switching time of just 15 msec.
• UF sensitivity: Superior sensitivity, repeatability, and linearity are achieved, thanks to the newly developed Qarray® optics.
• UFscanning: In MS scanning, a range of mass to charge ratios are determined in successive 0.1 m/z steps. This is controlled by applying a rapidly changing voltage to the quadrupole (quadrupole rods). By adopting Shimadzu’s proprietary scanning technology (Patent: US8188426), high ion transmission is achieved without sacrificing sensitivity or resolution, even during high-speed scans up to 15,000 u/sec. Very narrow UFLC peaks can now be properly detected in scan mode acquisition.

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LCMS-2050 | Single Quadrupole LC-MS

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LCMS-8050 | Triple Quadrupole LC-MS

Thanks to a heated ESI probe and the UFsweeper III collision cell, the Shimadzu LCMS-8050 achieves a level of sensitivity 30 times that of the LCMS-8030.The UF Technology, the ultrafast measurement technology built into the LCMS-2020 has further evolved, so measurements can now be performed even faster, without sacrificing data quality. At the same time, more compounds can now be measured in simultaneous qualitative and quantitative analysis. The system can be used in a wide range of fields for a variety of applications, such as quantitative analysis which requires high sensitivity, multicomponent simultaneous analysis, and screening.

LCMS-8050 features

• UFsensitivity^TM: High Sensitivity for Trace Quantitative Analysis
• UFswitching^TM: Polarity Switching Technology with No Compromise in Quality or Sensitivity
• UFscanning^TM: Simultaneous, Highly Reliable Quantitative and Qualitative Analysis
• UF-MRM^TM: High-Sensitivity High-Speed MRM at 555 ch/sec
• Engineered for Robustness and Easy Operation/Maintenance: Maintains High Sensitivity Even During Successive Demanding Analyses

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LCMS-8060NX | Triple Quadrupole LC-MS

The Shimadzu LCMS-8060NX is our flagship triple quadrupole LC/MS system with exceptional sensitivity and detection speeds. With our latest UFMS™ technology, this LC/MS/MS boasts increased robustness and ease-of-use, as well as an Analytical Intelligence function to streamline your analytical process and maximize your laboratory throughput.
Equipped with the new IonFocus™ electrospray unit and improved ion guides, the LCMS-8060NX delivers more reliable analysis and　maximized uptime. It also offers higher efficiency over all workflow steps, making it an ideal choice for pharmaceutical, clinical, and food/beverage companies seeking greater operational efficiency.

LCMS-8060NX features

• IonFocus™ unit: A newly-developed ESI probe with focus electrodes introduces ions into the mass spectrometer more efficiently, while expelling contaminants to reduce noise and provide more stable data. In addition, an improved heat-assist design promotes the ionization of a wide range of compounds. (Patented technology.)
• UF-Qarray™Ⅱ, UF-Lens™Ⅱ: Re-engineered ion guide improves robustness without compromising on sensitivity. Maintenance of UF-Qarray II
  and UF-Lens II can be performed easily without tools.
• Easy maintenance interface: The LCMS-8060NX inherits all the ease-of-maintenance of its predecessors. Both the desolvation line (DL), which introduces the sample into the vacuum, and the ESI capillary can be replaced easily and in a short time. The DL can be replaced while maintaining the vacuum, minimizing downtime.
• Robustness and Ease of Use: In the newly-developed IonFocus unit, the focus electrodes reduce sensitivity loss from matrix effects by expelling contaminants with greater efficiency.
• Intelligent Automation Improves Workflow Efficiency: The combination of the LCMS-8060NX and the Nexera™ series UHPLC provides a system with multiple Analytical Intelligence features, improving the efficiency of your entire workflow and maximizing analytical throughput.

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LCMS-8060 | Triple Quadrupole LC-MS

The Shimadzu LCMS-8060 features an optimized ion guide and new technologies incorporated in the ion transport optical system. As a result, the ion sampling efficiency and ion focusing capability are significantly increased, to achieve improved sensitivity, approx. 3 times better than that of the LCMS-8050. Inheriting the high-speed performance of the LCMS-8050, this flagship model in the UFMS series features both the world’s highest level of sensitivity and the world’s highest throughput. It is capable of detecting ultra trace components in complex matrices, which have been difficult to detect to date, both quickly and with high sensitivity. This will contribute to further improvements in data quality in all types of trace quantitative analysis applications, such as for biological samples, which requires the highest level of sensitivity.

LCMS-8060 features

• Sensitivity: By redefining the ion focusing capability on the UF-Qarray, the LCMS-8060 brings a meaningful impact to quantitative detection and opens new opportunities for scientists to deliver solutions that make a true difference.
• Speed: Inspired by the need to balance advanced high speed MS/MS detection technologies with unrivalled LC performance, we were the first mass spectrometry company in the world to deliver a scan speed of 15,000 u/sec and a polarity switching speed of 15 msec. In the LCMS-8060 the scan speed is now increased to 30,000 u/sec and a polarity switching speed of 5 msec making a real difference to working better and faster.
• Solutions: High-sensitivity quantitation of intact catecholamines (CAs) in human plasma.
• Stability: The robustness of the LCMS-8060 and modified ion optics was also assessed by injecting 2400 samples of femto-gram levels of alprazolam spiked into protein-precipitated human plasma extracts over a 6 day period (over 400 samples were injected each day). The RSD of peak area response was 5% over this test period, using a deuterated internal standard (alprazolam-d5) the RSD was 3.5%. As part of the robustness test the vacuum system was vented to model a transient power failure with no effect on signal response or baseline noise level.

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LCMS-9050 | Quadrupole Time-of-Flight LC-MS

The Shimadzu LCMS-9050 is a quadrupole Time-of-Flight (Q-TOF) mass spectrometer system designed with technologies developed for Shimadzu LCMS series models and that results in among the highest mass accuracy stability levels available. Shimadzu’s proprietary high precision temperature control system inhibits even tiny mass variations caused by external factors, so that the system can be used to measure accurate mass values without worrying about mass calibration. The stable positive/negative high-speed polarity switching technology enables the simultaneous analysis of positive ions/negative ions, contributing to new applications development and heightened analysis efficiency. To ensure that all users can perform analysis easily and efficiently, Shimadzu has aimed to simplify mass calibration, maintenance and other non-analysis procedures. Further, combining this system with Shimadzu’s renowned lineup of varied optional equipment enables greater utilization of the characteristics of Q-TOF while greatly expanding the range of data obtainable.

LCMS-9050 features

Simpler Accurate Mass Spectrometry

• Technologies inherited from the LCMS series
• Stable long-term mass accuracy
• Effortless tuning (Performance Assistant)
• Easy maintenance

Provides High-Speed Polarity Switching Even with TOF

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