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LCMS

Liquid chromatography mass spectrometry (LCMS) is an indispensable tool for quantitative and qualitative analysis in a wide range of fields, from pharmaceuticals and food science to environmental analysis. Liquid Chromatography-Mass Spectrometry (LC-MS) is an advanced analytical technique. It combines the physical separation capabilities of liquid chromatography (LC) with the mass analysis capabilities of mass spectrometry (MS). This powerful combination allows for the precise identification and quantification of complex mixtures of compounds. In LC-MS, the sample is first separated by liquid chromatography. Components are divided based on their interactions with the mobile and stationary phases. Once separated, these components are introduced into the mass spectrometer, where they are ionized and detected based on their mass-to-charge ratio. This process provides detailed molecular information, including molecular weight, structure, and quantity of the sample components. Industries such as pharmaceuticals, environmental analysis, food safety, and clinical diagnostics are ideal for LCMS. This is due to its high sensitivity, specificity, and ability to analyze a wide range of compounds.

Whether you are looking to maximize throughput, increase sensitivity for trace compound analysis, or install a compact LCMS system in a smaller lab space without losing out on workflow efficiency. Shimadzu provides a range of world-class LC/MS instruments and applications to meet your daily analysis needs. Unique automation features and intuitive software ensure a smooth analysis experience for both beginners and experts. Our product portfolio includes single quadrupole (SQ) LC-MS, triple quadrupole (TQ) LC-MS/MS, and quadrupole time-of-flight (Q-TOF) LC-MS/MS.

Browse Shimadzu’s full product range below.

FEATURED PRODUCTS

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LCMS-9030 | Quadrupole Time-of-Flight LC-MS

The Shimadzu LCMS-9030 quadrupole time-of-flight (Q-TOF) mass spectrometer is a powerful instrument that integrates the world’s fastest and most...

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LCMS-9030 | Quadrupole Time-of-Flight LC-MS

The Shimadzu LCMS-9030 quadrupole time-of-flight (Q-TOF) mass spectrometer is a powerful instrument that integrates the world’s fastest and most sensitive quadrupole technology with TOF capabilities for accurate mass measurement.

The LCMS-9030 provides superior sensitivity for quantitative and qualitative analysis of samples over a wide concentration rane, including ultra-trace compounds. Patented technologies ensure high resolution and excellent mass measurement accuracy (MMA), supporting structure elucidation and identification of unknown compounds. High throughput is achieved with Shimadzu’s unique acceleration technologies designed for high-speed data acquisition.

LCMS-9030 features

High-Efficiency Quadrupole Technologies

UFaccumulation™ (Pat. US 10020181): Ion accumulation in the collision cell, synchronized perfectly with short cycles of data acquisition, maximizes sensitivity.
UFgrating™ (Pat. US 9048082): Shimadzu’s world-class manufacturing capability has enabled the ion acceleration electrode to be made with substantial mechanical strength. This grating is able to withstand the high voltages needed for ultrafast ion pulsing.
UF-FlightTube™ (Patent Pending): Mass accuracy needs mass stability. Shimadzu’s temperature-controlled UF-FlightTube requires less frequent calibration, enabling you to run more samples.
iRefTOF™ (Pat. US 8772708, 9490114): A computationally ideal electrostatic field has become a reality. Meticulously manufactured plate electrodes are stacked to create a reflectron which turns ions with no compromise in resolution or sensitivity.

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LCMS-2020 | Ultra Fast Liquid Chromatograph

The Shimadzu LCMS-2020 is optimized for the Prominence UFLC/UFLCXR Ultra Fast Liquid Chromatograph. Novel patent-pending technologies offer significan...

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LCMS-2020 | Ultra Fast Liquid Chromatograph

The Shimadzu LCMS-2020 is optimized for the Prominence UFLC/UFLCXR Ultra Fast Liquid Chromatograph. Novel patent-pending technologies offer significantly enhanced scan speed and positive-negative ion polarity switching time, which are essential for UFLC, and simultaneously boost sensitivity. The instrument combines the excellent compound selectivity that is a feature of the mass spectrometer with significantly enhanced total productivity – from method development to analysis. The LCMS-2020 plays a useful role in a range of fields, including the synthesis of compounds in the pharmaceutical and chemical industries.

LCMS-2020 features

UF Switching: To detect both positive and negative ions, analysis is performed while switching between the positive and negative ionization modes. The LCMS-2020 adopts patented high-voltage power supply technology (Patent: US7855355) to achieve an ultra-fast polarity switching time of just 15 msec.
UF sensitivity: Superior sensitivity, repeatability, and linearity are achieved, thanks to the newly developed Qarray® optics.
UFscanning: In MS scanning, a range of mass to charge ratios are determined in successive 0.1 m/z steps. This is controlled by applying a rapidly changing voltage to the quadrupole (quadrupole rods). By adopting Shimadzu’s proprietary scanning technology (Patent: US8188426), high ion transmission is achieved without sacrificing sensitivity or resolution, even during high-speed scans up to 15,000 u/sec. Very narrow UFLC peaks can now be properly detected in scan mode acquisition.

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LCMS-2050 | Single Quadrupole LC-MS

The Shimadzu LCMS-2050 single quadrupole mass spectrometer combines the user-friendliness of an LC detector with the excellent performance of MS ...

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LCMS-2050 | Single Quadrupole LC-MS

The Shimadzu LCMS-2050 single quadrupole mass spectrometer combines the user-friendliness of an LC detector with the excellent performance of MS to provide a complete package of user-friendliness, high-level basic performance, and compactness. To make it as simple to use as possible, the system is packed with technology and functions to ensure that even users unfamiliar with mass spectrometers can easily and efficiently proceed with data acquisition. While enabling a sense of operational convenience and easy operability on par with an LC, it provides the high speed, high sensitivity, and wide mass range analysis carried over as features of Shimadzu mass spectrometers, so there are no compromises in its performance as an MS detector. It can target a wide range of compounds from low molecular to high molecular, and low-polarity to high-polarity, so the LCMS-2050 can be used in a variety of fields and applications. Further, as it is equipped with data analysis support functions using Analytical Intelligence as well as eco conscious functions, it also contributes to labor savings and energy savings in laboratories.

LCMS-2050 features

Seamless integration with LC by design

Eliminates the Installation and Training Costs of Introducing an MS
Sized for Integrated into LC Systems
Easy Parameter Settings for Seamless Operation
Mass-it: Adds Mass Information to UV Chromatograms Automatically

Superior detection for added confidence

Measures Compounds with a Wide Range of Characteristics
Optimal for High-Polymer Analysis
High-Speed MS Suitable for UHPLC

Streamlined operation for cost efficiency

Space Savings
Automatic Checks of Instrument Performance (Performance Concierge)
Environmental Responsibility
Easy Maintenance

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LCMS-9050 | Quadrupole Time-of-Flight LC-MS

The Shimadzu LCMS-9050 is a quadrupole Time-of-Flight (Q-TOF) mass spectrometer system designed with technologies developed for Shimadzu LCMS series m...

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LCMS-9050 | Quadrupole Time-of-Flight LC-MS

The Shimadzu LCMS-9050 is a quadrupole Time-of-Flight (Q-TOF) mass spectrometer system designed with technologies developed for Shimadzu LCMS series models and that results in among the highest mass accuracy stability levels available. Shimadzu’s proprietary high precision temperature control system inhibits even tiny mass variations caused by external factors, so that the system can be used to measure accurate mass values without worrying about mass calibration. The stable positive/negative high-speed polarity switching technology enables the simultaneous analysis of positive ions/negative ions, contributing to new applications development and heightened analysis efficiency. To ensure that all users can perform analysis easily and efficiently, Shimadzu has aimed to simplify mass calibration, maintenance and other non-analysis procedures. Further, combining this system with Shimadzu’s renowned lineup of varied optional equipment enables greater utilization of the characteristics of Q-TOF while greatly expanding the range of data obtainable.

LCMS-9050 features

Simpler Accurate Mass Spectrometry

Technologies inherited from the LCMS series
Stable long-term mass accuracy
Effortless tuning (Performance Assistant)
Easy maintenance

Provides High-Speed Polarity Switching Even with TOF

New Shimadzu technology: UFstabilization™
Stability and high mass accuracy
A world of new applications
Eco-friendly

Accommodates a Variety of Needs

Diversity of optional equipment
Convenience of PESI × LCMS-9050
Comprehensiveness of SFC × LCMS-9050

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Nexera MX | Innovation in Multiplex Analysis

Double your sample throughput and simplify batch analysis with the Shimadzu Nexera MX multiplex LC/MS system. The MX Dual Stream Technology (MX...

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Nexera MX | Innovation in Multiplex Analysis

Double your sample throughput and simplify batch analysis with the Shimadzu Nexera MX multiplex LC/MS system.

The MX Dual Stream Technology (MX-DST) system allows near-continuous data acquisition and halves analysis times for batch analysis compared to conventional LC/MS analysis.

LabSolutions Connect™ software improves workflow efficiency by speeding up the labor-intensive tasks of MRM optimization, method creation and batch creation. A quick and efficient judgment function reduces data screening time for continuous multiplex analysis.

Nexera MX features

Double sample throughput with the same method: The Nexera™ MX Dual Stream Technology (MXDST) uses the existing method as is and enables processing twice the number of samples in the same time it takes for conventional systems.
Quick and automatic optimization of MRM conditions: The newly developed LabSolutions Connect ™ improves the efficiency of required pre-analysis tasks, such as MRM optimization, method creation, and batch creation.
Simple Workflow Supports High Throughput: Nexera MX simplifies real-time batch analysis and provides an excellent judgment function that enables effective screening of a large number of analytical results obtained from continuous multiplex analysis.

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Nexera Mikros | Microflow LCMS System

Improvement in the sensitivity of an LC/MS/MS method can generally be achieved by reducing the analytical scale of the analysis. However, reducin...

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Nexera Mikros | Microflow LCMS System

Improvement in the sensitivity of an LC/MS/MS method can generally be achieved by reducing the analytical scale of the analysis. However, reducing the analytical scale significantly to nano-flow reduces the throughput, stability, and robustness as a trade-off for greater sensitivity. Nexera Mikros, a Shimadzu microflow LC/MS system, offers a balanced solution to increased sensitivity with less compromise to throughput and robustness, using flow rates from 1 to 500 μL/min and column I.D. from 0.1 to 1 mm. It achieves stable and sensitive quantitative analysis through robust performance of microflow solvent delivery, optimized ion source design, the unique UF-Link column connection, and system variety that supports a wide range of applications.

Nexera Mikros features

Improved Detection Limits with Microflow

High Bioanalytical Sensitivity: Sensitivity remains a challenge for many vitamin D metabolites, such as 1,25(OH)2 di-hydroxyvitamin D and 24,25(OH)2 di-hydroxyvitamin D, because they lack easily ionizable functional groups and are in low-abundance. As shown below, microflow LC/MS/MS analysis of standard solutions of the aforementioned vitamin D analytes resulted in a three- to five-fold improvement in the signal-to-noise ratio when compared to semi-microflow analysis.
Monoclonal Antibody Bioanalysis – Nexera™ Mikros and nSMOL™ Antibody BA Kit: nSMOL (nano-surface and molecular orientation limited proteolysis) is a proprietary, ground-breaking process that enables selective proteolysis of the Fab region of antibodies using trypsin-immobilized nanoparticles. Fab-derived peptides are quantified via MRM measurement on a high-sensitivity mass spectrometer. The Nexera Mikros system achieved signal intensities 12 times higher than with conventional flow rates, with a corresponding lower limit of detection of 0.025 μg/mL and good linearity. The Nexera Mikros system is ideal for low-level quantitation of peptides by LCMS.

Incomparable Microflow Ruggedness

Realize the Benefits of Microflow While Enjoying the Ruggedness and Reliability of HPLC: The Nexera Mikros system delivers the improvements you expect from a low-flow system with the ruggedness of HPLC. A plasma blank was protein precipitated, diluted (3x), and injected 1,500 times consecutively. During the consecutive injections, QC sample (40 ppt of nortriptyline) was injected once every 50 injections of plasma blank. Peak areas and retention times of QC sample are plotted below. With 4.38% RSD area repeatability and 0.25% RSD retention time stability, extremely stable operation was demonstrated, without loss of peak shape common in high-throughput analyses of complex matrices.

Easy, Familiar Operation

Micro-ESI™ Sources: Shimadzu’s Micro-ESI LCMS source has been designed for optimal sensitivity and ease of use. An X–Y adjustable stage and viewing camera allow for easy ESI spray needle adjustment. The column oven is mounted on the LCMS to minimize the volume between the exit of the column and the ESI needle.
The Micro-ESI probe also features an ESI spray angle optimized for microflow rates, and is available for triple quadrupole mass detection mass spectrometryand quadrupole time-of-flight mass spectrometry, respectively.
CTO-Mikros™ + UF-Link™: Easy, Dependable Column Installation: Mounted to the Micro-ESI source is the CTO-Mikros column oven. Stable column temperature, essential to retention time reproducibility, is ensured and columns up to 150 mm in length can be accommodated. To preserve the optimal source adjustment, the CTO-Mikros features an innovative snap-in column locking system, the UF-Link.
LC-Mikros™: Innovative Microflow Pump Design: Shimadzu LC pumps are the industry standard for long life and high performance. The LC-Mikros solvent delivery pump has completely new direct-drive engineering to deliver micro to semi-micro flow rates ranging from 1 to 500 μL/min. UHPLC system pressure tolerance of 80 MPa (11,600 psi) allows the use of every column type.
SIL-40C XR: Low-Volume Direct Injection Autosampler: The SIL-40C XR autosampler delivers you excellent accuracy and reproducibility as well as extremely low carry-over. Its injection volume ranges from 0.1 to 50 μL and your precious sample has never wasted due to the total injection method SIL-40C XR adapted.

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LCMS-TQ RX Series

Shimadzu‘s LCMS-TQ RX Series expands the capability and productivity of triple quadrupole mass spectrometer with performance that can be relied ...

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LCMS-TQ RX Series

Shimadzu‘s LCMS-TQ RX Series expands the capability and productivity of triple quadrupole mass spectrometer with performance that can be relied upon. The RX Series has been designed to generate a highly focused ion beam from the ion source to detector bringing together advanced ion guide and collision cell technologies. The result is higher data quality that makes an impact on any LC-MS/MS assay

LCMS-TQ RX Series Overview

Improving data reliability with high stability and measurement sensitivity
In mass spectrometers that ionize samples by spraying them, the uniformity of the spray affects the stability of measurements. The LCMS-TQ RX Series uses a newly developed CoreSpray nozzle in the ion source to make the spray uniform, thus improving the stability of analytical data. In addition, IonFocus* utilizes fluid analysis and electric field analysis technology to efficiently introduce ions into the MS, removing contaminant components and achieving a higher measurement sensitivity.
Streamlines lab operations through automatic calibration
The PERFORMANCE CONCIERGE function automatically checks the device status (e.g. mass accuracy, spectral intensity) before measurement begins and fine-tunes the device as needed. Optimal performance is thereby assured and downtime reduced.
Optimizes power consumption to reduce energy use and cost
In ecology mode, the instrument monitors its status and automatically shuts down when the device is not in use. Conventionally, the inside of the instrument continues to be heated even after measurements are finished. By minimizing this, power consumption is reduced by approximately 31 %.

* This proprietary Shimadzu ion source provides high sensitivity and durability by eliminating contaminant components. It does so through the efficient intake of ions to the mass spectrometer, utilizing the techniques of fluid and electric field analysis. Conventionally, only the LCMS-8060NX was equipped with this.

LCMS-TQ RX Series Lineup

LCMS-8060RX

The LCMS-8060RX builds on the exceptional sensitivity and UF capabilities of the LCMS-8060NX and adds even more robustness without compromising sensitivity.

LCMS-8050RX

Engineered to deliver excellent sensitivity the LCMS-8050RX further extends the performance of the LCMS-8050 to meet the ever-changing needs of any LC-MS/MS laboratory.

LCMS-8045RX

Designed for rugged, routine LC-MS/MS analysis with the optimal balance of cost, sensitivity and performance now enhanced with greater robustness and easier to use.

Streamlined sensitivity with Shimadzu

The LCMS-TQ RX Series models are the latest in Shimadzu’s tireless development of precision instruments that increase analytic performance while reducing the time, cost, complexity and environmental impact of the essential lab work at the heart of modern science and industry. Through this series, Shimadzu will heighten the efficiency of laboratory work related to pharmaceuticals, food product development and environmental inspection, contributing to the growth of research and development in healthcare, green transformation and other sectors.

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