Non-Targeted PFAS Screening Using High-Resolution Q-TOF LC-MS

Detection of Unknown PFAS Isomers and Residual Contaminants | On-Demand Webinar

Duration: 49 minutes
Format: On-demand
Registration: Free (registration required)

This webinar forms part of Shimadzu’s PFAS in Focus technical series and and builds on targeted PFAS analysis by addressing the limitations of conventional LC-MS/MS workflows.

While triple quadrupole mass spectrometry enables sensitive targeted detection of PFAS, it provides an incomplete picture of contamination due to the presence of unknown isomers and emerging compounds.

This webinar introduces non-targeted PFAS screening using high-resolution Q-TOF LC-MS, combined with advanced PFAS-specific data processing, enabling detection and identification of a broader range of fluorinated compounds without detection bias.

What This Webinar Covers

During this 60-minute technical session, you will learn how to:

• Apply non-targeted PFAS screening using high-resolution Q-TOF LC-MS
• Detect unknown PFAS isomers and a broader range of fluorinated compounds
• Understand how PFAS-specific data processing improves compound identification
• Implement high mass accuracy workflows for complex environmental samples

The session concludes with an expert Q&A addressing practical implementation and analytical challenges.

Why Non-Targeted PFAS Screening Is Required

Targeted LC-MS/MS methods are essential for regulatory compliance but provide a limited view of PFAS contamination due to the presence of unknown isomers and emerging compounds.

Non-targeted screening using high-resolution mass spectrometry enables laboratories to:

• Identify unknown or emerging PFAS compounds
• Expand analytical scope beyond regulated target lists
• Improve environmental risk assessment
• Complement existing targeted workflows

Advances in PFAS-specific data processing now allow more effective interpretation of complex high-resolution datasets, improving compound identification and reducing analytical bias.

This approach is increasingly important as regulatory frameworks evolve and awareness of PFAS diversity increases.

Part of the PFAS in Focus Technical Series

PFAS in Focus is a 10-part technical webinar programme sponsored by Shimadzu, covering analytical strategies for PFAS testing across multiple platforms.

The series includes:

• Targeted PFAS analysis using LC-MS/MS
• Non-targeted screening using Q-TOF LC-MS
• Volatile PFAS detection using GC-MS
• Total fluorine measurement using AOF and CIC

This session focuses specifically on high-resolution, non-targeted PFAS screening workflows.

Featured Instrumentation

This webinar highlights high-resolution Q-TOF LC-MS systems for PFAS screening and identification.

Explore:

• Shimadzu LCMS-9030 Q-TOF LC-MS
• Shimadzu LCMS-9050 Q-TOF LC-MS

Who Should Attend

• Environmental testing laboratories performing PFAS analysis
• Drinking water and wastewater utilities
• Academic researchers working in environmental contamination
• LC-MS users expanding into PFAS screening applications