Alternative PFAS Analysis Techniques: GC-MS, HS-SPME and AOF by CIC

Complementary Approaches for PFAS Compounds Beyond Traditional LC-MS Workflows | On-Demand Webinar

Duration: 60 minutes
Format: On-demand
Registration: Free (registration required)

This webinar forms part of Shimadzu’s PFAS in Focus technical series and explores alternative analytical approaches for PFAS compounds that may not be fully addressed using traditional LC-MS methodologies.

The demand for per- and polyfluoroalkyl substances (PFAS) analysis continues to grow as laboratories respond to evolving regulatory requirements and emerging contaminants. While many standardised PFAS methods rely on liquid chromatography coupled with mass spectrometry (LC-MS), the diverse physicochemical properties of PFAS compounds can make alternative analytical techniques necessary.

This session introduces complementary approaches that expand analytical coverage beyond conventional targeted and non-targeted LC-MS workflows.

What This Webinar Covers

During this 60-minute technical session, you will learn how to:

• Apply alternative analytical techniques for complementary PFAS analysis
• Address volatile PFAS compounds that are challenging to analyse using traditional LC-MS methods
• Utilise Gas Chromatography-Mass Spectrometry (GC-MS) workflows for volatile PFAS detection
• Understand the use of Head-Space Solid Phase Microextraction coupled with Triple Quadrupole GC-MS (HS-SPME GCMS-TQ) for water analysis
• Explore Adsorbable Organic Fluoride (AOF) analysis using Combustion Ion Chromatography (CIC)

The session concludes with an expert Q&A addressing practical implementation and analytical considerations.

Why Alternative PFAS Analysis Techniques Matter

Many established PFAS methods focus on compounds that are readily analysed using LC-MS. However, not all PFAS compounds exhibit the same chemical behaviour.

Alternative analytical approaches can help laboratories:

• Detect volatile PFAS compounds not ideally suited to LC-MS workflows
• Expand analytical coverage beyond targeted compound lists
• Assess total fluorinated content using complementary techniques
• Build a more comprehensive understanding of PFAS contamination

Combining multiple analytical approaches can provide a more complete picture of environmental PFAS contamination.

Beyond Targeted and Non-Targeted LC-MS

While targeted LC-MS/MS and high-resolution Q-TOF workflows remain essential tools for PFAS testing, some compounds require alternative analytical strategies.

This webinar demonstrates how GC-MS methodologies and Adsorbable Organic Fluoride (AOF) analysis can complement existing PFAS workflows and help laboratories address analytical gaps.

Part of the PFAS in Focus Technical Series

PFAS in Focus is a 10-part technical webinar programme sponsored by Shimadzu, covering analytical strategies for PFAS testing across multiple platforms.

The series includes:

• Targeted PFAS analysis using LC-MS/MS
• Non-targeted screening using Q-TOF LC-MS
• Volatile PFAS detection using GC-MS
• Total fluorine measurement using AOF and CIC
• Practical laboratory implementation and expert discussion

This session focuses on analytical techniques that complement conventional PFAS testing workflows.

Featured Instrumentation

This webinar highlights analytical platforms used for complementary PFAS analysis, including:

• Shimadzu GCMS-TQ8050 NX Triple Quadrupole GC-MS
• Shimadzu Gas Chromatography systems
• Advanced autosampler solutions for GC workflows

Explore Mason Technology’s range of GC-MS systems and environmental analysis solutions.

Who Should Attend

• Environmental testing laboratories performing PFAS analysis
• Drinking water and wastewater utilities
• Academic researchers working in environmental chemistry and contamination studies
• LC-MS users looking to expand PFAS testing capabilities
• Laboratories seeking complementary approaches to PFAS analysis